Against the odds : the story of AIDS drug development, politics, and profits / Peter S. Arno and Karyn L. Feiden.
1992
RA644.A25 A76 1992 (Map It)
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Details
Author
Title
Against the odds : the story of AIDS drug development, politics, and profits / Peter S. Arno and Karyn L. Feiden.
Published
New York : HarperCollins, [1992]
Copyright
©1992
Call Number
RA644.A25 A76 1992
Edition
First edition.
ISBN
0060183098 (cloth) :
Description
xviii, 314 pages ; 24 cm
System Control No.
(OCoLC)25051149
Bibliography, etc. Note
Includes bibliographical references (pages 273-302) and index.
Record Appears in
Added Author
Table of Contents
Acknowledgments
Introduction
Cast of Characters
1
Unlikely Heroes
1
2
A New Virus: The Search for Magic Bullets
10
3
The FDA and the Public Interest
22
4
The AZT Breakthrough
37
5
Placebos and Profiteering
48
6
The Rise of the AIDS Underground
60
7
Activism, ACT UP, and Dextran Sulfate
71
8
The Pentamidine Saga
83
9
Loosening the Regulatory Leash
97
10
Grassroots Trials Come of Age: Activists Seizing Control
110
11
Business as Usual: The Patenting and Pricing of AZT
125
12
On the Defensive: Pentamidine Profits and a Corporation Under Siege
142
13
Absence of Vision: The Ganciclovir Scandal
157
14
Parallel Track and the Promise of ddI
172
15
Research on Trial: The Limits of the Government System
186
16
AIDS and Women, Children, and Minorities
198
17
The Illicit Compound Q Trials
207
18
The ddI Milestone
216
19
Crashing the Gates: Activists Enter the Drug Testing Sanctum
225
Conclusion
236
Appendix A: Milestones in AIDS Drug Development
247
Appendix B: How a Clinical Trial Is Designed
261
Appendix C: The Challenge to the AZT Patent
267
Sources
273
Index
303